Sub-Torcular Cranial Venous Outflow in Intracranial Venous Hypertension: Anatomic and Hemodynamic Insights Following Venous Sinus Stenting.
Venous sinus stenosis is a recognized cause of venopathic intracranial hypertension (VIH) and a therapeutic target in idiopathic intracranial hypertension (IIH). Previously observed sub-torcular venous collateral flow is poorly classified, and their dynamics following venous sinus stenting (VSS) rem…
Idiopathic Intracranial Hypertension, Basic Concepts and Emerging Molecular, Genetic, and Immunological Therapies.
Idiopathic intracranial hypertension (IIH) is a chronic disorder characterized by elevated intracranial pressure (ICP) without an identifiable intracranial mass lesion or abnormal cerebrospinal fluid (CSF) composition. Traditionally viewed as a disorder of impaired CSF absorption or venous outflow o…
Spatial Distribution of Perivascular Spaces on MRI Is Associated with Disease Severity in Idiopathic Intracranial Hypertension.
Glymphatic dysfunction, affecting cerebrospinal fluid transport and clearance, is increasingly implicated in idiopathic intracranial hypertension (IIH). Because perivascular spaces (PVS) reflect glymphatic activity, we evaluated whether their volume and spatial distribution could serve as imaging ma…
Molecular evidence of aquaporin-4 dysregulation and neuroinflammatory stress underlying blood-brain barrier dysfunction in idiopathic intracranial hypertension: A case-control study.
To evaluate aquaporins (AQP), heat shock proteins (HSP), and CD146 (cluster of differentiation) as molecular markers of blood-brain barrier (BBB) disruption and neuroinflammation in idiopathic intracranial hypertension (IIH). Emerging evidence implicates BBB dysfunction and neuroinflammati…
Glymphatic system in temporal lobe epilepsy associated with encephalocele.
Temporal lobe encephaloceles (ENCs) are underdiagnosed causes of drug-resistant temporal lobe epilepsy (TLE), frequently associated with idiopathic intracranial hypertension (IIH). Emerging evidence suggests glymphatic system dysfunction in both IIH and TLE. We investigated glymphatic markers in TLE…
A 24-year-old previously healthy woman with a high body mass index presented with a several week history of poor vision in the left eye associated with non-positional headaches. Examination was notable for Frisén grade 2 bilateral optic disc swelling with a visual acuity of 20/20-1 in the right…
Extensive Cerebral Venous Sinus Thrombosis With Obstructive Hydrocephalus in a Young Female With Underlying Essential Thrombocythemia: A Case Report.
Persistent symptoms suggestive of idiopathic intracranial hypertension despite standard therapy should prompt urgent neuroimaging to exclude cerebral venous sinus thrombosis. When CVST is confirmed without an obvious provoking factor, evaluation for underlying myeloproliferative neoplasms, including…