Tick-borne pathogens in dogs and their ticks in France: Molecular and serological evidence from a multicenter participatory study.
Canine tick-borne diseases (TBDs) are expanding globally, representing an increasing concern for both veterinary and public health. Dogs, due to their close contact with humans and frequent exposure to ticks, may serve as valuable sentinels for zoonotic risk. Between December 2022 and December 2023,…
Nanotechnology-mediated podocyte injury repair: mechanistic exploration and therapeutic prospects.
Podocyte injury serves as a central pathological driver in chronic kidney diseases (CKD), including diabetic kidney disease (DKD) and IgA nephropathy (IgAN). However, conventional therapies are still limited by poor targeting efficacy and systemic side effects. Nanotechnology provides transformative…
The behavioural spillover effect: modelling behavioural interdependencies in multi-pathogen dynamics.
During the recent pandemic, a rise in COVID-19 cases was followed by a decline in influenza. In the absence of cross-immunity, a potential explanation for the observed pattern is behavioural: non-pharmaceutical interventions (NPIs) designed and promoted for one disease also reduce the spread of othe…
A physiology-informed microRNA framework for urothelial carcinoma in hemodialysis patients.
Urothelial carcinoma (UC) is a major cancer globally and disproportionately frequent among hemodialysis (HD) patients. Currently, there are no reliable blood-based clinical markers to detect or monitor this cancer in HD population. In this research, we investigate the functional roles of these miRNA…
Molecular detection of Borrelia burgdorferi sensu lato in questing ticks: One year of sampling in Bologna (Northern Italy).
Borrelia burgdorferi sensu lato (s.l.) includes several genospecies responsible for Lyme borreliosis (LB), a major zoonotic disease transmitted by Ixodes spp. ticks. In Western Europe, LB incidence has risen in recent decades, with documented expansion into previously non-endemic regions. A cross-se…
The current landscape and future directions of Lyme disease vaccines.
Lyme disease (LD) represents a significant public health challenge in North America and Eurasia. The persistent increase in its incidence may create an opportunity for vaccines to gain broader acceptance. Recent years have seen notable advances in vaccine development. However, achieving a balance be…
Oridonin ameliorates ulcerative colitis by regulating the PI3K/AKT/mTOR signaling pathway to activate autophagy.
The present study aimed to investigate the therapeutic effects and underlying mechanism of oridonin (ORI) in ulcerative colitis (UC) using the lipopolysaccharide (LPS)‑induced macrophage inflammatory model in vitro and the dextran sulfate sodium (DSS)‑induced mouse UC model in vivo. Ce…
Using Electronic Health Records to Enhance Lyme Disease Surveillance: Protocol for the SubLyme Network.
Lyme disease is the most common vector-borne illness in the United States. The limitations of traditional surveillance strategies for Lyme disease affect the ability to reliably track its burden and evaluate interventions. The US Centers for Disease Control and Prevention (CDC) established the Surve…