The behavioural spillover effect: modelling behavioural interdependencies in multi-pathogen dynamics.
During the recent pandemic, a rise in COVID-19 cases was followed by a decline in influenza. In the absence of cross-immunity, a potential explanation for the observed pattern is behavioural: non-pharmaceutical interventions (NPIs) designed and promoted for one disease also reduce the spread of othe…
Nanotechnology-mediated podocyte injury repair: mechanistic exploration and therapeutic prospects.
Podocyte injury serves as a central pathological driver in chronic kidney diseases (CKD), including diabetic kidney disease (DKD) and IgA nephropathy (IgAN). However, conventional therapies are still limited by poor targeting efficacy and systemic side effects. Nanotechnology provides transformative…
Glycolytic reprogramming in host response to Borrelia burgdorferi: A gene signature revealed by integrative bioinformatics analysis and machine learning.
Lyme disease (LD), a multifaceted condition caused by Borrelia burgdorferi (Bb), remains poorly understood, particularly regarding metabolic pathways. This study aimed to evaluate the role of glycolysis-related genes (GRGs) in LD pathogenesis and identify key genes and mechanisms relevant to diagnos…
Lyme Borreliosis in Iran: True or myth? A systematic review.
Despite growing global attention to Lyme disease (LD), its epidemiology remains poorly defined in the Middle East, including Iran. This systematic review addresses a critical gap by synthesizing available evidence on LD occurrence, vectors, and reservoirs in Iran. We followed PRISMA guidelines to sy…
Impact of Printing Orientation on the Surface Properties and Microbial Biofilm Formation of 3D-Printed Denture Resins.
This study aimed to characterize the adhesion and biofilm formation of key denture-associated microbes-Candida albicans, Porphyromonas gingivalis, and Streptococcus mutans-on a 3D-printed photopolymer resin (FotoDent®). Discs were fabricated at three distinct printing orientations (0°, 45&…
Protective efficacy of mutant strains of Borrelia burgdorferi as potential reservoir host-targeted biologics against Lyme disease.
Lyme disease (LD), caused by Borrelia burgdorferi (Bb), is the most common vector-borne disease in the United States. Novel strategies to control transmission of Bb to humans via ticks are critical for the prevention of LD. One such strategy is to leverage non-infectious mutant strains of Bb for pat…
Gut immune and redox transcriptional responses to Borrelia infection in questing Ixodes ricinus.
Ticks of the genus Ixodes are major vectors of pathogens of medical and veterinary importance, including the causative agents of Lyme borreliosis. While much is known about tick immune responses during feeding, the molecular mechanisms that enable pathogen persistence during the off-host period rema…
CSF immunoglobulin (IgG) often informs diagnosis in CNS inflammatory disease- qualitatively (oligoclonal bands; OCBs), or quantitatively (CSF: serum IgG: albumin, e.g. IgG index). Most US laboratories estimate excess CSF IgG using linear models, most in Europe, Reiber's hyperbolic model - the latter…