Motor-related white matter tracts are prominently affected in primary trigeminal neuralgia.
Primary trigeminal neuralgia (PTN) is a severe chronic pain disorder, yet whole-brain white matter microstructural alterations beyond the trigeminal nerve remain poorly understood, partly due to limitations of conventional diffusion tensor imaging in crossing fiber regions. We prospectively enrolled…
Surgical Management of Trigeminal Neuralgia Emerging in the Long-Term after Cerebellopontine Angle Tumor Surgery without Tumor Regrowth.
Cerebellopontine angle tumors are reported causes of trigeminal neuralgia, but trigeminal neuralgia emerging long after cerebellopontine angle tumor removal, despite the absence of tumor regrowth, is extremely rare. Surgical resolution is required for intractable cases, but it is challenging due to…
Microvascular Decompression for Trigeminal Neuralgia - How Far Yet and How Far to Get.
This study aims to share a single surgeon's experience among patients with primary and secondary trigeminal neuralgia (TGN) managed with microvascular decompression (MVD), detailing immediate and last follow-up results and identifying the prognostic factors associated with various outcomes and recur…
Gray matter plasticity associated with secondary trigeminal neuralgia in rats.
This study aims to characterize brain regional structural alterations across distinct time points in a rat model of trigeminal neuralgia using MRI. A rat model of secondary trigeminal neuralgia was established by injecting a talc suspension into the infraorbital foramen. Sixty Sprague-Dawley rats we…
The cerebrospinal fluid-contacting nucleus CGRP-RAMP1-PKA signaling pathway mediates trigeminal neuralgia and its mechanism.
Trigeminal neuralgia (TN) is prevalent form of neuropathic pain (NP). Its regulatory circuits and mechanisms remain unclear. The authors' previous work demonstrated that the cerebrospinal fluid-contacting nucleus (CSF-contacting nucleus) participates in the regulation of NP induced by sciatic nerve…
MRI Distortion Correction Produces Geometrically Relevant Shifts in Cisternal Trigeminal Nerve Localization: Implications for Gamma Knife Radiosurgery.
Gamma Knife radiosurgery (GKRS) for trigeminal neuralgia (TN) requires millimeter-scale accuracy because a single 4-mm collimator targets the cisternal trigeminal nerve (CTN). MRI is essential for CTN visualization but is vulnerable to geometric distortion, particularly near the skull base. This stu…
How Percutaneous Balloon Compression Is Performed Today: Technical Adaptations for Trigeminal Neuralgia in the Absence of Commercial Kits.
Percutaneous balloon compression is an established treatment of medically refractory trigeminal neuralgia and remains a commonly performed percutaneous procedure for patients requiring immediate pain relief. Historically, the procedure was standardized through dedicated commercial instrument kits de…
Gamma Knife radiosurgery in patients with indwelling deep brain stimulator systems.
Deep brain stimulation (DBS) is an established therapy for medically intractable movement disorders but poor response or habituation may prompt noninvasive salvage strategies. Stereotactic radiosurgery (SRS) offers targeted lesioning with a favourable risk profile, yet feasibility in patients with i…