Motor-related white matter tracts are prominently affected in primary trigeminal neuralgia.
Primary trigeminal neuralgia (PTN) is a severe chronic pain disorder, yet whole-brain white matter microstructural alterations beyond the trigeminal nerve remain poorly understood, partly due to limitations of conventional diffusion tensor imaging in crossing fiber regions. We prospectively enrolled…
Surgical Management of Trigeminal Neuralgia Emerging in the Long-Term after Cerebellopontine Angle Tumor Surgery without Tumor Regrowth.
Cerebellopontine angle tumors are reported causes of trigeminal neuralgia, but trigeminal neuralgia emerging long after cerebellopontine angle tumor removal, despite the absence of tumor regrowth, is extremely rare. Surgical resolution is required for intractable cases, but it is challenging due to…
Painful tic convulsif: Dual neurovascular compression within the spectrum of cranial nerve hyperactive dysfunction syndromes.
Concurrent trigeminal neuralgia (TN) and hemifacial spasm (HFS), historically termed painful tic convulsif, is a rare manifestation of cranial nerve hyperactive dysfunction associated with neurovascular compression. The operative anatomy may involve independent conflicts affecting cranial nerves V a…
Pearls & Oy-sters: Bilateral Neuropathic Facial Pain With Autonomic Features and Neurovascular Contact.
Trigeminal neuralgia (TN) is an uncommon disorder, with an annual prevalence of 0.03%-0.3% in North America. It is typically unilateral, most commonly involving the V2 and V3 distributions and may be accompanied by mild autonomic features. We report a 35-year-old woman who developed severe right mor…
Manual and automated capture of analgesic-responsive facial pain behaviors of unrestrained mice in a trigeminal neuralgia model.
Trigeminal neuralgia (TN), a devastating neuropathic pain condition, profoundly affects human well-being. Despite an initial response to carbamazepine (CBZ), many patients become refractory to pharmacotherapy and subsequent invasive procedures. Although preclinical trigeminal neuropathic pain models…
Evaluation of corneal subbasal nerve plexus as a predictor of radiosurgery outcome in trigeminal neuralgia.
Gamma Knife radiosurgery (GKRS) is an established treatment for trigeminal neuralgia (TGN); however, no validated biomarkers exist to predict outcomes. In vivo confocal microscopy (IVCM) allows noninvasive quantification of corneal subbasal nerve plexus (SBP) and dendritic cell (DC) density, potenti…
Advances in needle-based interventions for chronic neuropathic pain.
Chronic neuropathic pain, arising from somatosensory system dysfunction, presents significant therapeutic challenges due to pathogenic complexity, individual variability, and limitations of current pharmacotherapies. Needle-based interventions, characterized by minimal invasiveness, dual analgesic-n…
Assessment of pain relief and sensory dysfunction outcomes after CyberKnife radiosurgery for trigeminal neuralgia using detailed radiobiologic dose modeling: Results from a retrospective study on large international patient cohort.
To evaluate clinical outcomes and identify patient- and treatment-related predictors of pain relief onset, long-term pain control, and sensory dysfunction in patients with medically refractory trigeminal neuralgia (TN) treated with CyberKnife radiosurgery (CKRS), incorporating radiobiologic modeling…