Repeat radiofrequency thermocoagulation for multiple sclerosis-associated versus idiopathic trigeminal neuralgia: a comparison of long-term pain control.
Radiofrequency thermocoagulation (RFT) of the gasserian ganglion provides rapid pain relief in trigeminal neuralgia (TN) and is minimally invasive. In multiple sclerosis (MS)-associated TN (MS-TN), recurrence may be more frequent than in idiopathic/classic TN (Id-TN), possibly due to demyelinating p…
Differentiating Trigeminal Neuralgia From Persistent Idiopathic Dentoalveolar Pain and Persistent Idiopathic Facial Pain in Oral and Maxillofacial Surgery.
The diagnostic distinction between trigeminal neuralgia (TN), persistent idiopathic dentoalveolar pain, and persistent idiopathic facial pain remains a challenge for oral and maxillofacial surgeons. While neurovascular compression is often viewed as a definitive indicator for surgical intervention,…
How I do it: Endoscopic microvascular decompression with vertebral artery transposition for trigeminal neuralgia caused by vertebrobasilar dolichoectasia.
Vertebrobasilar dolichoectasia (VBDE) is an uncommon cause of trigeminal neuralgia (TN), in which an ectatic vertebral artery (VA) compresses the root entry zone (REZ), while perforators may limit safe transposition. Fully endoscopic microvascular decompression with VA transposition was performed. P…
Quantitative Sensory Testing Identifies Altered Thermal and Pain Processing in Trigeminal Neuralgia.
This cross-sectional study aims to assess somatosensory function in patients with trigeminal neuralgia (TN) using quantitative sensory testing (QST) and QST-based sensory phenotyping, and to investigate their relationship with clinical findings, including etiology (classical and idiopathic TN), type…
Long-term effects of carbamazepine on bone-related biochemical markers in patients with epilepsy.
Carbamazepine (CBZ) is a commonly prescribed antiseizure medication frequently prescribed for epilepsy, trigeminal neuralgia, and mood disorders. However, CBZ is a strong inducer of cytochrome P450 enzymes, which can accelerate the catabolism of vitamin D and potentially alter bone metabolism. This…
Ultrasound-Guided Mandibular Nerve Pulsed Radiofrequency With Adjunct Dexamethasone in Trigeminal Neuralgia: A Retrospective Cohort Study.
This study aimed to evaluate the clinical outcomes and safety of ultrasound-guided pulsed radiofrequency (PRF) targeting the mandibular nerve (V3) with adjunct low-dose perineural dexamethasone in patients with trigeminal neuralgia (TN). We retrospectively analyzed 73 consecutive patients treated be…
Suicidal ideation among patients with facial pain disorders.
Facial pain can be severely debilitating. Although etiologies vary, facial pain commonly results in diminished quality of life and a pronounced psychosocial burden. To determine whether severe facial pain is associated with a heightened risk of suicidal ideation. We performed a retrospective review…
Use of Suzetrigine for Treatment of Refractory Trigeminal Neuralgia in Four Patients: A Small Case Series.
Suzetrigine selectively blocks the NaV1.8 voltage-gated sodium channel in peripheral neurons. Trigeminal neuralgia (TN) is a neuropathic pain syndrome affecting the trigeminal nerve and is traditionally treated with nonselective sodium channel blockers. No studies have evaluated Suzetrigine for TN,…