Research papers, community discussions, and videos across 76 chronic illness conditions. All sourced from PubMed, Reddit, and YouTube via official APIs — no scraping, no personal data stored.
What You Need to Know About Sacroiliac Dysfunction.
Low back pain is the leading cause of disability worldwide, and sacroiliac dysfunction is estimated to occur in 15%-30% of those with nonspecific low back pain. Nurses are in the unique position to support and provide education to patients who may be experiencing sacroiliac dysfunction or possibly a…
Peristomal Pyoderma Gangrenosum Related to Systemic Lupus Erythematosus: A Case Study.
Peristomal pyoderma gangrenosum (PPG) is a rare complication of peristomal skin. It is difficult to manage, and there are no guidelines for treatment. This case study describes the management of a patient with PPG while taking corticosteroids and cyclosporine as chronic therapy for systemic lupus er…
Examining Cost Differences in Malignant Brain and Central Nervous System Tumor Treatment Across US Military Health System Care Settings.
The objectives of this study were to determine whether the cost of care for malignant brain and other central nervous system tumors (MBT) in the US Military Health System differs between the Department of War-operated direct care (DC) network and the affiliated civilian-operated private sector care…
Glomerulus-Targeted Nanotherapy via Collagen IV-α3 Binding Enhances Renal Immunoregulation in Lupus Nephritis.
Lupus nephritis requires long-term immunosuppressive therapy, which is often associated with severe systemic side effects. Therefore, new therapeutic strategies that maintain high efficacy while minimizing adverse effects is essential. Although nanomedicine has advanced systemic and kidney-targeted…
Efficacy and safety of filgotinib in patients with active radiographic and nonradiographic axial spondyloarthritis: results from OLINGUITO, a phase 3 trial consisting of 2 randomised, placebo-controlled, double-blind, parallel-group studies.
This study aimed to investigate the efficacy and safety of filgotinib, a JAK1 preferential inhibitor, in patients with axial spondyloarthritis (axSpA). The phase 3 OLINGUITO trial comprises 2 international, randomised, double-blind, placebo (PBO)-controlled studies. Patients with an established diag…
Polyglycolic Acid Shield Prevents Repeated Delayed Bleeding After Endoscopic Stricturotomy for Anastomotic Stricture in Crohn's Disease: A Case Report.
Endoscopic stricturotomy (ES) is a novel approach for treating benign strictures of the lower gastrointestinal tract. However, it is performed at a limited number of facilities, and strategies for preventing complications have not yet been established. We performed ES for ileo-sigmoid anastomosis as…
Adverse Pathological Features and Worse Prognosis in Rectal Cancer Compared With Colon Cancer in T1 and T2 Stages.
Emerging endoscopic techniques are expanding opportunities for minimally invasive therapy in early colorectal cancers (CRCs). Data regarding the clinicopathological features and outcomes of colon versus rectal cancers in Tis, T1, and T2 stages remain limited. This study evaluates and compares these…
Third Space Endoscopic Therapies for Benign Motility Disorders: A Narrative Review.
To review the evidence base, evolution, outcomes, adverse events (AEs), and management for third-space endoscopy (TSE) procedures for management of benign motility disorders. This review examines TSE procedures for motility disorders, reviewing the current available techniques, success, outcomes, an…
Going high-throughput: Dynamic conformations and interactions in vivo.
Proteins are intrinsically dynamic molecules that continuously explore conformational ensembles to execute biological functions. Conventional structural biology methods rely on in vitro reconstitution of purified components and therefore capture predominantly static snapshots, often overlooking the…
Revisiting the anatomy of the retroperitoneum and renal fascia. Aspects applied to ra-diology, laparoscopic and robotic surgery - a narrative review.
This review aims to provide a comprehensive analysis of the anatomy of the retroperitoneal and abdominal fascias. We analyzed papers published in the past 70 years in the databases of Pubmed, Embase and Scielo. We excluded case reports, editorials and opinions of specialists. Studies were excluded i…
Rosmarinic acid-cerium nanocatalysts enable oxygenation-enhanced ROS neutralization and PET imaging-guided therapy for acute kidney injury.
Acute kidney injury (AKI) is driven by a vicious interplay among excessive reactive oxygen species (ROS) accumulation and persistent renal hypoxia, which collectively disrupt redox homeostasis and exacerbate tubular injury. However, current therapeutic strategies primarily provide supportive care an…
A dual-targeting mRNA lipid nanoparticle restores ABCA1-dependent cholesterol homeostasis to promote repair of age-related bone defects.
Cholesterol regulates autophagy and aging, yet its role in bone marrow mesenchymal stem cell (BMSC) senescence remains unclear. We demonstrate that ABCA1 palmitoylation is associated with its lysosomal localization and lysosome-associated cholesterol transport, thereby contributing to autophagy inhi…
Reversing zinc dyshomeostasis and oxidative stress: A metallothionein 1-activating MXene/Zn2+ triple-action nanotherapeutic strategy for chronic non-bacterial prostatitis.
Chronic non-bacterial prostatitis (CNP), a prevalent and debilitating urological disorder affecting 8.4% of men aged 15-60 years, presents significant clinical challenges due to the paucity of targeted therapies and poor patient adherence. To address this unmet medical need, we developed an innovati…
Kidney biopsy in patients with small kidneys: diagnostic yield and treatment modification in a retrospective cohort study.
Reduced renal size has traditionally been considered a relative contraindication to kidney biopsy because of the perception that advanced chronic damage provides limited diagnostic or therapeutic benefit. However, the actual clinical value of renal biopsy in patients with small kidneys remains insuf…
Systematic identification of bacterial neuraminidase inhibitors from Psoralea corylifolia using ultrafiltration-UPLC-Q-Orbitrap-MS and molecular dynamics.
Bacterial neuraminidase (BNA) is a potential target for discovering anti-infective agents. Here, the BNA inhibitory activity of the ethanolic extract of Psoralea corylifolia (EEPC) was investigated using integrated experimental and computational approaches. Affinity ultrafiltration-UPLC-Q-Orbitrap-M…
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